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apalutamide will reduce the extent or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medication which are CYP2C19 substrates can result in lower publicity to these medicines.diazepam will boost the amount or impact of ruxolitinib by